Isolated single‐cell suspension of tumor cells (Fig 1I) from TNBC, ovarian, lung, and colon tumor cellular and TNBC PDX xenografts showed higher total and surface PD‐L1 expression from animals treated with DR5 agonist antibodies as compared to IgG1 control (Fig 1J and K, Appendix Fig S3A–C). Here, CD274 is linked to neoplasm.