(3) The expression levels of inflammatory factors (IL-1β and IL-6) in cerebrospinal fluid were higher in patients with AD than those of healthy controls and patients with VD, which were positively correlated with GSDMD expression.<h4>Conclusion</h4>The expression of GSDMD was increased in patients with AD, which could be used as a biomarker for AD diagnosis and identification from VD. Here, IL1B is linked to Alzheimer disease.