ELISA kit was purchased to determine the levels of GSDMD, T-Tau, Tau181p, and Aβ<sub>1-42</sub> in cerebrospinal fluid, and the expression of inflammatory factors, IL-1β and IL-6, was also detected.<h4>Results</h4>(1) The levels of GSDMD, T-Tau, and Tau181p in the cerebrospinal fluid were higher in patients with AD than those of patients with VD and healthy controls, while the levels of Aβ<sub>1-42</sub> in the cerebrospinal fluid were lower in patients with AD than that in healthy controls and patients with VD. Here, GSDMD is linked to Alzheimer disease.