We have previously established that osteoclastogenesis can be induced by both antioxidant enzyme peroxiredoxin‐4 (PRDX4) (Rafiei et al., 2015) and L‐plastin (Tiedemann et al., 2019), which is an actin‐bundling protein secreted by human breast and prostate cancer cells. Here, PRDX4 is linked to Familial prostate cancer.