In this scenario, here, we also investigated the prognostic value of Acrp30, leptin, and of their receptors in thyroid cancer patients consulting The Cancer Genome Atlas (TCGA-THCA) dataset [7], and we found that a better overall survival (OS) and relapse-free survival (RFS) are significantly correlated with low level of leptin receptor and with high level of Acrp30, respectively. This evidence concerns the gene LEPR and thyroid cancer.