In order to gain insight into the mechanisms and genes that are required for the action of nitrogen-containing-bisphosphonates (N-BPs), Yu et al. performed a CRISPRi-mediated genome-wide screen in cancer cells and in this way identified the solute carrier family 37 member 3 gene (SLC37A3) as altering responses to alendronate [45]. The gene discussed is SLC37A3; the disease is cancer.