CCN2 and Duchenne muscular dystrophy: At the myotube stage, a fibrosis‐related gene set was clearly up‐regulated in DMD cells, as illustrated by the overexpression of ANGPT1, CTGF, collagens (e.g. COL1A2), matrix metallopeptidases (MMPs), and tissue inhibitors of metallopeptidase (TIMPs) (Figure5B).