Upregulated/hypomethylated genes from the pooled transcriptome analysis in Turner et al., (2019b) included 22 genes associated with ECM/actin structure and remodeling (MSN, CTTN, FLNB, TIMP3, ITGB3, LAMA5, COL4A1, THBS1), mechano‐transduction (CRK, CD63), protein synthesis (GSK3β) and TGF‐β (FOS, SMAD3, WNT9A), calcium (ITPR, ADCY3), IL‐6 (STAT3), retinoic acid (RARA) signaling, coagulation (F2LR3), angiogenesis (KDR), histone methylation (DOT1L), and tumor suppression (RASSF5). The gene discussed is ADCY3; the disease is neoplasm.