RFXAP and pancreatic neoplasm: In a similar fashion, exosomes enriched in miR-212-3p and isolated from pancreatic cancer cells when taken up by DC cells downregulate the regulatory factor X-associated protein (RFXAP) expression, which subsequently decreases MHC class II expression and results in the inactivation of CD4+ T cells, contributing to the generation of an immunotolerant microenvironment in PDAC (64).