INS and type 2 diabetes mellitus: ITAS has previously shown that insulin-naïve people with T2DM, uncontrolled on OADs and/or non-insulin injectables can effectively and safely self-titrate Gla-300 (in the absence of SU/glinides treatment), with no differences in terms of HbA1c reduction or risk of hypoglycaemia versus physician-managed titration [5].