CFTR and cystic fibrosis: Lumacaftor/ivacaftor (LUMA/IVA, Orkambi®), approved for CF patients homozygous for the Phe508del CFTR mutation, includes a medication correcting intracellular processing of CFTR (the corrector lumacaftor) with one that increases the open probability of the abnormal CFTR channel (the potentiator ivacaftor).