Further clinical efficacy has recently been documented with the introduction of triple therapy, i.e. combining second-generation correctors, such as VX-445 (elexacaftor) to tezacaftor–ivacaftor, in CF patients homozygous for the Phe508del CFTR mutation [26] and also in those for whom no CFTR modulators are currently applied [27]. The gene discussed is CFTR; the disease is cystic fibrosis.