Concerning the treatment of an acute cerebrovascular event (stroke or TIA) in an adult with HbSS, emergent CT and CTA should be performed, oxygen supplementation is recommended, and exchange blood transfusion should be started immediately upon recognition of symptoms (ideally within 2 h of acute neurological symptom onset) if the Hb is under 8.5 g/dL aiming for a target Hb > 10 g/dL. This evidence concerns the gene GSTM1 and stroke disorder.