In this in silico study, we analyzed ACE2 and CXCL10 in terms of expression pattern, functional characterization and mutation in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) to assess their possible involvement in the severe prognosis of COVID-19 in patients with lung cancer. This evidence concerns the gene CXCL10 and lung adenocarcinoma.