As shown in Table 2, CMTM1 expression was significantly associated with the family history and TNM stage of HCC patients (P < 0.05), while had no relationship with other clinicopathological features of HCC patients, such as gender, age, smoking, alcohol intake, HBV infection, liver cirrhosis, serum alpha-fetoprotein (AFP), tumor diameter, tumor number, or metastasis. This evidence concerns the gene AFP and neoplasm.