BMI was independently associated with LAD (β = 0.328, p < 0.001), after adjustment for age, gender, hypertension, diabetes, dyslipidemia, usage of ACEI/ARB, eGFR, SUA, hs-CRP, TC, LDL-C, cTNI, resting LVOTPG ≥ 30 mm Hg, moderate or severe MR, systolic anterior motion (SAM), LVESV index, SV index, CO index, LVM index. The gene discussed is CRP; the disease is metabolic syndrome.