Of note, this study presents a comparative analysis of glutamine metabolic changes reported in other viral infections and cancer cells against SARS-CoV-2 infection, suggested the modulation of GLS1, PSAT1, HIF-1α, mTORC1, GFAT1/2, and Myc factors as a conceivable approach to modulate the glutamine metabolism for the inhibition of SARS-CoV-2 pathogenesis. Here, HIF1A is linked to cancer.