JAK/STAT signaling plays an important role in the pathogenesis of diabetic nephropathy (Chuang and He, 2010; Matsui and Meldrum, 2012; Brosius and He, 2015), and this pathway has been shown to promote proliferation in renal glomerular mesangial cells (Wang et al., 2002). The gene discussed is SOAT1; the disease is diabetic kidney disease.