Several pathways are associated with its activation in GBM cells; the extracellular signal-regulated kinase1/2 (ERK1/2) pathway (Scherz-Shouval et al., 2007), class I phosphatidylinositol 3-phosphate kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway (Fan et al., 2010), and nuclear factor kappa-B (NF-κB) pathway. The gene discussed is MTOR; the disease is glioblastoma.