However, TNC gene silencing after subarachnoid hemorrhage (SAH) was found to alleviate neuronal inflammation and apoptosis via phosphoinositide-3-kinase (PI3K)/Akt/nuclear factor (NF)-κB pathway activation and has been highlighted as a potential therapeutic target to prevent neuronal cell death after injury (Shiba et al., 2014; Liu et al., 2018). Here, TNC is linked to subarachnoid hemorrhage.