Consistent with the studies of FXTAS inclusions by Ma et al. (2019), we observed modest, but significantly increased abundances of small ubiquitin-like modifier 1 (SUMO1)/SUMO1P1 and SUMO2 proteins in FXTAS cortex (50% increase in SUMO1 protein; 20% increase in SUMO2). This evidence concerns the gene SUMO1 and fragile X-associated tremor/ataxia syndrome.