TNF and severe acute respiratory syndrome: From this analysis, we spotted that both the deregulated genes of SARS-CoV-2-infection and the SARS-CoV-2-interacting human proteins are involved in several important immune signaling pathways, namely, IL-17 signaling, NF-kappaB signaling, TNF signaling, Toll-like receptor signaling, phagosome, apoptosis, necroptosis, PI3K-Akt signaling, HIF-1 signaling, and MAPK signaling (Figure 3).