CD8A and type 1 diabetes mellitus: In addition, the overexpression of miR-23b, miR-98, and miR-590-5p in CD8+ T-cells from T1DM patients was suggested to target apoptotic genes (TRAIL, TRAIL-R2, FAS, and FASLG), resulting in the excessive proliferation of autoreactive T-cell and T1DM development (66).