NLRP3 and psoriasis: In this article, we show that TTP is downregulated in fibroblasts derived from the skin of psoriasis patients compared to those obtained from healthy individuals; we provide evidence that these cells display higher inflammasome activity than their normal counterpart, and we show that TTP restoration determines a decrease in inflammasome activation that depends on the ability to directly target for degradation of NLRP3 mRNA, as reported in macrophages by Haneklaus et al. (21).