Neuronal expression of RAGE is also well documented (Sasaki et al., 2001), with this receptor heavily implicated in the pathogenesis of neurodegenerative disorders, particularly Alzheimer’s disease (Cai et al., 2016), and in contributing to neurological sequelae associated with diabetes (Toth et al., 2007) and other systemic pathologies with an inflammatory element (Gasparotto et al., 2019). This evidence concerns the gene AGER and early-onset autosomal dominant Alzheimer disease.