As expected, we observed a significant association between the homozygous HES1 promoter variant and disease phenotype (18.92% of cases vs. 9.91% of controls; OR: 2.291, 95% CI: 1.637–3.207, p = 9.72 × 10−7, Table 2) in the CHD cases and healthy controls. Here, HES1 is linked to coronary artery disorder.