For example the low-density lipoprotein receptor-related protein 1B (Lrp1b), which is downregulated in CRC, can suppress the growth and migration of cancer cells via inhibiting the interaction between Dvl2 and the Axin and hence the Wnt/β-catenin signaling (Wang et al., 2017). The gene discussed is LRP1B; the disease is colorectal carcinoma.