LRP6 and breast cancer: The receptors Fz2, Fz3, Fz6, Fz7, and Fz10 as well as the co-receptor Lrp6 have also been reported to significantly increase in breast cancer and contribute to mesenchymal-like stemness, invasion, metastasis, and drug resistance (Liu et al., 2010; Yang et al., 2011; Gong et al., 2014; Simmons et al., 2014; Bell et al., 2017; Corda et al., 2017; Yin et al., 2020).