Although the majority of the studies conducted in primary clinical tissue have suggested a higher expression of the Rspo receptor Lgr5 in CRC cells relative to the adjacent normal tissue, a tumor-promoting role and enhanced chemoresistance, several studies have reported a potential tumor suppressive function of Lgr5 in CRC progression (Hsu et al., 2013; Morgan et al., 2018). Here, LGR5 is linked to colorectal carcinoma.