EGFR and breast cancer: For example, breast cancer cell lines with high levels of epidermal growth factor receptor (EGFR) have been found to be resistant for the tyrosine kinase inhibitors (TKIs) targeting EGFR because of EGFR accumulation in the lipid rafts at the membranes of these cells and pharmacological depletion of cholesterol from the rafts decreased this resistance (Irwin et al., 2011).