The polyether ionophore antibiotic salinomycin, the milk thistle flavonolignan silibinin, the natural phenol echinacoside and the natural plant polyphenol rottlerin have all been shown to inhibit Wnt/β-catenin signaling by suppressing the Wnt co-receptor Lrp6 expression and exert anti-tumor effects in TNBC (Lu et al., 2012, 2014; Lu and Li, 2014; Tang et al., 2020). This evidence concerns the gene LRP6 and neoplasm.