N-terminal mutations of Rnf43, one of the most commonly mutated genes in CRC, have also been linked with enhanced Wnt/β-catenin signaling activity in colon cancer while C-terminal truncation mutants act similarly to the wild-type Rnf43 (Giannakis et al., 2014; Li et al., 2020). Here, RNF43 is linked to malignant colon neoplasm.