AMER1 and cancer: The Cancer Genome Atlas (TCGA) consortium report reveals that Wnt signaling is altered in up to 93% of all sporadic CRCs with at least one and up to sixteen alteration(s) in Wnt pathway components including APC, CTNNB1, TCF7L2, DKK family members, AXIN2 and the pathway negative regulator FAM123B/WTX (Cancer Genome Atlas Network, 2012).