Wnt3a and Wnt7a are likewise upregulated in metastatic breast cancer cell lines in association with poor prognosis and inhibition of Wnt/β-catenin signaling via Wnt1 knockdown could efficiently suppress cell proliferation and tumor growth (Jang et al., 2015; Avgustinova et al., 2016). This evidence concerns the gene WNT1 and breast cancer.