FZD7 and colorectal carcinoma: Apart from these Wnt ligands, various Fz receptors including Fz4, Fz7, and Fz10, are also upregulated in CRC and their elevated levels have been associated with increased stemness, metastasis and recurrence (Cancer Genome Atlas Network, 2012; Ye et al., 2019; Chi et al., 2020).