In addition to the Wnt ligands, high levels of Fz2, Fz7, Lrp5, and Lrp6 in HCC have also been found to be promote cell proliferation, migration, invasion, and EMT (Merle et al., 2004; Yuzugullu et al., 2009; Tung et al., 2012; Ou et al., 2019). The gene discussed is FZD7; the disease is hepatocellular carcinoma.