In a recent analysis of correlation between expression of Wnt ligands and 23 immunosuppressive genes across all cancer types in the TCGA dataset, high levels of Wnt1 has been found to significantly and negatively correlate with CD8 + T cells, showing that it induces immune resistance in lung adenocarcinoma cells and thus immunologically cold tumors (Kerdidani et al., 2019). Here, WNT1 is linked to cancer.