WNT7A and neoplasm: Wnt7a and its receptor Fz9 are significantly downregulated in NSCLC compared to normal uninvolved lung tissue and, upon interaction; they likewise trigger a tumor suppressor pathway by inhibiting transformed cell growth and promoting epithelial differentiation through activation of JNK pathway but not the Wnt/ß-catenin pathway (Winn et al., 2005).