In search of novel potential therapeutic targets for HCC, the tumor-promoting function of Fz7 could be effectively reverted by small interfering RNAs that suppressed proliferation and metastasis of HCC cells and enhanced their apoptosis and sensitivity to chemotherapeutic drugs (Chen et al., 2016, 2018; Xue et al., 2018). Here, FZD7 is linked to hepatocellular carcinoma.