During recent years, several E3 enzymes, such as F-box protein atrogin-1, muscle ring finger-1, TRAF6, and CDC20 have been reported to play roles in the development of cardiac hypertrophy through different mechanisms (Arya et al., 2004; Li et al., 2004, 2007; Ji et al., 2016; Xie et al., 2018). Here, TRAF6 is linked to cardiac hypertrophy.