To further verify the involvement of GRP78-mediated activation of ER stress in TAC-induced cardiac hypertrophy in SOCS3cko mice, SOCS3f/f and SOCS3cko mice were administered 4-PBA, a reported inhibitor of ER stress that can attenuate pressure overload-induced hypertrophy (Luo et al., 2015). Here, HSPA5 is linked to cardiac hypertrophy.