Among them, we found that atRA specifically induced miR-4680-3p expression, which in turn suppressed expression of ERBB2 and JADE1. While expression of some predicted genes targeted by miR-4680-3p was not changed by miR-4680-3p overexpression in HEPM cells, these genes may be regulated by a combination of other miRs or through feedback loops reported in several cancer cell lines and in C2C12 cells, an immortalized mouse myoblast cell line (Hou et al., 2019; Liu et al., 2019; Quan et al., 2019). Here, JADE1 is linked to cancer.