DSCAM and Dravet syndrome: These molecules owe their name to the location of human DSCAM within the DS critical region of chromosome 21 (Yamakawa et al., 1998; Schmucker and Chen, 2009), which is considered to be crucially involved in the emergence of cognitive phenotypes associated with DS (Delabar et al., 1993; Korenberg et al., 1994; Belichenko et al., 2009, 2015; Aziz et al., 2018).