RYR2 and catecholaminergic polymorphic ventricular tachycardia: Finally, a new optogenetic animal model using nematodes with mutations in proteins analogous to mutations in the RyR2 or calsequestrin in CPVT patients displayed similar muscular dysfunction findings upon a stress challenge with a faster pacing rate; muscular dysfunction was prevented with the use of S107 (Fischer et al., 2017).