In a mouse model of lung cancer, activation of Dll1-mediated Notch signaling limited tumor angiogenesis as well as tumor progression; it also enhanced the efficacy of anti-EGFR targeted therapy, highlighting the therapeutic potential for Notch signaling pathway given its effects in shaping the TME, especially in enhancing anti-tumor T cell immunity (Biktasova et al., 2015). The gene discussed is DLL1; the disease is neoplasm.