HOTTIP and hereditary clear cell renal cell carcinoma: Another report has demonstrated that lncRNA Activated in renal cell carcinoma with sunitinib resistance (lncARSR) can be delivered to sensitive cells via exosomes to disseminate sunitinib resistance, and it might act as a predictor and a novel therapeutic target for sunitinib resistance (Qu et al., 2016), which was similar to our findings that EV-mediated transfer of lncRNA HOTTIP conferred mitomycin resistance in CRC.