Previous studies have confirmed that CD4+ T cells, upon differentiation, may acquire various functions, including blocking cytotoxic NK cells and activating CD8+ T cells, suppressing harmful immunological reactions to self- and foreign antigens, and aiding CD8+ T cells in tumor rejection (Crouse et al., 2015; Rosenberg and Huang, 2018; Long et al., 2019). Here, CD8A is linked to neoplasm.