MEIS1 and malignant colon neoplasm: Furthermore, we preliminarily used methylation data in TCGA to investigate the downregulation cause of MEIS1 in colon cancer and found that the expression of MEIS1 has a negative association with MEIS1 methylation (Figure 11D); what is more, MEIS1 methylation was more in tumor than normal tissue in colon cancer (P < 0.001; Figure 11E).