Cancer cells have several immunosuppressive mechanisms, including increasing the levels of various immunosuppressive cells, such as Treg cells and macrophages, elevating levels of various immunosuppressive molecules, and decreasing the expression of cancer antigens, which together result in the dysfunctioning of CD8+ T cells to recognize cancer cells (Pardoll, 2012; Long et al., 2019). Here, CD8A is linked to cancer.