LEP and obesity due to melanocortin 4 receptor deficiency: Moreover, obesity is a prevalent manifestation of metabolic disorders, and accumulating evidence has demonstrated that TC, TG, LDL-C, INS, and LEP levels were significantly higher in obese than in normal weight people, while the concentrations of ADP and ghrelin decreased (Yildiz et al., 2004; Addante et al., 2011).