In contrast, the formation of its enantiomer d-2-hydroxyglutarate (dr-2HG) is catalyzed by a mutated version of isocitrate dehydrogenase 1 or 2 (IDH1/2) contributing to the pathogenesis of cancer, whereas l-2HG biosynthesis does neither involve IDH1 nor IDH2. This evidence concerns the gene IDH1 and cancer.