RIGI and neoplasm: Apart from primary cells, discrete components of the immune system like mediators, checkpoints, tumor-associated macrophages (TAMs), Tumor-associated fibroblasts (TAFs), toll-like receptors (TLRs), myeloid-derived suppressor cells (MDSCs), nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), and C-type lectins, etc. could also be utilized for immunomodulation (Song et al., 2017; Le et al., 2019).