SOCS family proteins were considered as the important regulators of inflammatory responses (like interferons and cytokines; IL6, TNFα) and being significantly induced by broad range of bacterial infections (Stoiber et al., 2001; Yasukawa et al., 2003; Demirel et al., 2013; Carow and Rottenberg, 2014; Duncan et al., 2017; Alice et al., 2018). This evidence concerns the gene CISH and bacterial infectious disease.