SP100 and cytomegalovirus infection: Notably, this group contained the known HCMV restriction factors Sp100, MORC3, DAXX, and HLTF in addition to cell cycle regulating protein ANAPC1, all of which have been reported to be degraded during HCMV infection by ourselves and others (Figure 2B) (Tran et al., 2010a; Chen et al., 2011; Kim et al., 2011; Tavalai et al., 2011; Schreiner and Wodrich, 2013; Sloan et al., 2016; Nightingale et al., 2018).