Studies have shown that lncRNA CNC-TIM3 exacerbates CD8 T cell failure by binding to TIM-3 in hepatocellular carcinoma (23), and down-regulating lncRNA NEAT1 can inhibit apoptosis of CD8+ T cells and increase the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma (24). This evidence concerns the gene HAVCR2 and neoplasm.