Furthermore, heparanase and Hpa2 supported the adhesion of RPMI8266 (Supplementary Figure 1B) and U266 myeloma cells that normally grow in suspension, and this was similarly abrogated by heparin (Figure 1C), suggesting that the pro-adhesive properties of Hpa2 are mediated primarily by HS. This evidence concerns the gene HPSE and plasma cell myeloma.