MYCN and retinoblastoma: The restricted expression pattern of N-myc during development may be mirrored in human tumors since cancers with a neural cell origin like neuroblastoma, medulloblastoma, retinoblastoma, astrocytoma and glioblastoma, as well as, hematological malignancies frequently overexpress MYCN. However, overexpression of MYCN has also been reported in Wilms tumors, rhabdomyosarcomas, prostate, pancreatic and lung cancers (17).