ROC analysis demonstrated the ability of methylated KCNQ5 alone, methylated C9orf50 alone, and the combination of methylated KCNQ5 and methylated C9orf50 to discriminate CRC from NEDs with AUC values of 0.846 (95% CI: 0.802–0.890), 0.904 (95% CI: 0.869–0.940), and 0.888 (95% CI: 0.849–0.928), respectively (Figure 3B). This evidence concerns the gene C9orf50 and colorectal carcinoma.