The elevated expression of ETS1 in the nucleus induces expression of HK1 and PFKFB3 and rescues the decrease of HCC cell proliferation induced by miR-139-5p in SK-Hep-1 and SMMC-7721 cells, indicating that ETS1 probably plays a carcinogenic role in HCC (35). This evidence concerns the gene ETS1 and hepatocellular carcinoma.