CD4 and cancer: By taking the median value as threshold and using CIBERSORT as TILs component analysis, T cells CD4 memory activated (in 26 tumor types) expressed the most extensive infiltration differences in pan-cancer tissues and followed by Macrophages M1 (in 24 tumor types), T cells CD8 (in 20 tumor types), Macrophages M0 (in 15 tumor types) between the high- and low-expression groups of CD274 (Supplement Figure 1).