CXCL8 and breast cancer: Here, it is important to indicate that in contrast to the above-mentioned findings on CXCL8-mediated down-regulation of BC cells at growing phase (161), CXCL8 and other members of the ELR+ CXC sub-group of chemokines are generally and largely considered as key promoters of cell proliferation and viability in BC [reviewed in (50)]; thus, it is assumed that such chemokines would often enhance re-emergence from dormancy.