In addition, a recent study concerning the TNFα receptor TNFR2 in TNBC and luminal-A BC cells indicated that its down-regulation has improved the efficacy of adriamycin; TNFR2-mediated resistance was taking place through inhibition of adriamycin-induced pH2AX expression, mediated by enhanced expression of poly(ADP-ribose) polymerase (PARP) (112). The gene discussed is TNFRSF1B; the disease is breast cancer.