Particularly, a recent study that has analyzed cross-tolerance of breast tumor cells to anthracyclines (doxorubicin), which has developed in taxane (doxetaxel)-resistant cells, indicated that inflammatory cytokines and NF-κB were involved in the process (114); this investigation has indicated that GM-CSF + IL-23 + IFNγ, as well as NF-κB-mediated signaling induced the expression of CD44 by taxane-resistant cells, initiating signaling and metabolic cascades that regulated cross-tolerance (114). Here, NFKB1 is linked to breast neoplasm.