These findings have a high clinical relevance in view of the fact that chemotherapy has led to increased CXCR2 expression in BC patients; moreover, increased CXCR1/CXCR2 and CXCL8 expression levels were significantly correlated with poor overall and disease-free survival in studies of the TCGA dataset and of patient biopsies (103, 122). This evidence concerns the gene CXCL8 and breast cancer.