What’s more, when in the stage of transplanting to the bone, E-cadherin and E-cadherin adherent junction formed between cancer cells, then the E-cadherin and N-cadherin adherent junction formed between cancer cells and osteoblasts, and cell-cell contact promoted the tumor proliferation via activated mTOR pathway in tumor microenvironment (46). The gene discussed is MTOR; the disease is neoplasm.