Particularly, in contrast to their low CNV frequencies (< 5%) in normal samples, CBLL1, METTL14, RBM15, IGF2BP1, YTHDC1, and YTHDF2 exhibited more than 20% difference in their frequencies of CNVs between tumor and normal samples (Figure 1B and Table S2). This evidence concerns the gene METTL14 and neoplasm.