Among the 593 probes located in these 28 genes, 23 probes located on 6 genes, including CBLL1, FTO, IGF2BP1, IGF2BP2, IGF2BP3, and ZNF217, showed significant differences in their methylation patterns between tumor and normal samples (|Δbeta-value| > 0.2 and P < 0.05) (Figure 1D). The gene discussed is FTO; the disease is neoplasm.