NOTCH1 and melanoma: In addition, various altered transcripts resulting from SF3B1 mutation were linked with diverse signaling pathways; decreased MAP3K7 expression leading to increased NF-kB activity (15), decreased expression of the uveal melanoma tumor suppressor gene BRD9 resulting in disruption of the non-canonical BAF chromatin-remodeling complex (30), decreased phosphatase 2A subunit PPP2R5A leading to MYC stability (21), and an alternative transcript of DVL2 was linked to overexpression of NOTCH1 in CLL (18).