In addition, various altered transcripts resulting from SF3B1 mutation were linked with diverse signaling pathways; decreased MAP3K7 expression leading to increased NF-kB activity (15), decreased expression of the uveal melanoma tumor suppressor gene BRD9 resulting in disruption of the non-canonical BAF chromatin-remodeling complex (30), decreased phosphatase 2A subunit PPP2R5A leading to MYC stability (21), and an alternative transcript of DVL2 was linked to overexpression of NOTCH1 in CLL (18). Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.