To explore the biological functions of these hub genes, KEGG pathway and GO term enrichment analyses were performed using the clusterProfiler package in R. The results of the KEGG pathway analysis showed that these dysregulated genes were enriched in cancer-associated pathways, including the JAK-STAT, PI3K-Akt, NOD-like receptor, and Rap1 signaling pathways (Figure 1F). The gene discussed is AKT1; the disease is cancer.