Moreover, secretion of immunoregulatory soluble factors from both MM and BM microenvironment cells including transforming growth factor TGF-β, interleukin IL-10, IL-6, prostaglandin E2, and APRIL; as well as adhesion of MM cells to extracellular matrix proteins and accessory cells further promotes immune evasion and inhibition of apoptosis (5). The gene discussed is IL6; the disease is Miyoshi myopathy.