Elegant mechanistic studies identified cereblon (CRBN) as a major target for IMiDs in MM cells, and showed that they induce growth arrest and caspase-8–mediated apoptosis, associated with CRBN-dependent degradation of Ikaros (IKZF1) and aiolos (IKZF3) transcription factors, followed by IRF4 downregulation (24, 127, 128). The gene discussed is IKZF3; the disease is Miyoshi myopathy.