In tumor masses, M2 microglia are associated with protumorigenic activities that are capable of stimulating tumor growth through several cytokines and chemokines like IL-10, monocyte chemotactic protein-1 (MCP-1/CCL2), some metalloproteinases (MMPs), and ARG1 (13, 42, 58, 59). This evidence concerns the gene CCL2 and neoplasm.