Concerning the mutation type, one missense mutation in UCH-domain of UCHL3, two missense mutations in UCHL5, two missense mutations and one truncating mutation in BAP1. A web-based tool GEPIA (164) analysis revealed UCHL1 gene expression in HNSCC tissues is significantly elevated as compared to normal tissues, which is different from the previous studies in nasopharyngeal carcinoma (71) (Figure 3A). The gene discussed is UCHL1; the disease is head and neck squamous cell carcinoma.